Christina Applegate is facing a battle more challenging than any role she’s ever played.**

**The “Dead to Me” star, 52, opened up about her profound struggle with depression due to her multiple sclerosis diagnosis.**

**In a candid episode of her and Jamie-Lynn Sigler’s “MeSsy” podcast, she revealed, “I’m in a depression right now, which I don’t think I’ve felt that for years.”**

**Applegate described her current state as a “real, f–k-it-all depression” that is scaring her with its fatalistic feelings.**

**She admitted, “I’m trapped in, like, this darkness right now that I haven’t felt [in], like, I don’t even know how long, probably 20-something years.”**

**This raw confession came after a surprise appearance at the 2024 Emmy Awards, where Applegate received a standing ovation.**
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